Is this what popeye looks like ? in Disease Diagnosis/ Treatments Posted March 18, 2016 · Edited March 18, 2016 by 210 Oranda How long did you do the metro/triple sulfa combo? Kanaplex is extremely hard on the kidneys. The build up of fluid in popeye and/or dropsy is due to the kidneys not working properly/effectively. If an organ is already struggling, I avoid any meds that are hard on them. If the metro/triple sulfa isn't strong enough, I would go with metro and oxytetracycline . . . . 2 weeks of metro(powder), triple sufla & epsom.. (12 days to be exact) Where to find oxytetracycline ??