Hey newb and sorry to hear you're having troubles. Medicating fish is soooo tricky. We've all talked on here about "shotgun" medicating, but I understand thats not what you're doing. Flukes infect the gills from what I've understood which would cause them to "yawn" trying to backflush the gills, and possibly would cause them to stay at the surface. The floating upside down sounds more like a swb issue, which one of the helpers or mods could give you more advice on. I don't think the Prazi is causing this, as Prazi should routinely be used for any new fish and doesn't harm your cycle.
I'm sure you know that any time you medicate the ammonia and nitrites need to be 0, and stay there for the meds to be effective. I would definitely do a large wc if I were you, and make sure the temp and ph are the same as to not stress out Esteban any more than he is.
Possibly you could answer all the questions at the top so we can see if there's anything not right in your water. Does Esteban have anything that looks like grains of salt on him?
Good luck and don't get discouraged. Hopefully this will get figured out.