Hi. Although a few have said that they've treated their tanks with a low dose of salt and they've been fine,most everything I've read or dealt with cautions you on Pleco's and salt. And personally,I would definately say no to a full salt dip on your Pleco.A low % in a body of water is one thing,but doing at least a 0.3% dip or more-which is normally recommended for Parasites ,I feel would do your Pleco in for sure.